5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride

Name: 5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride
Brand: ChemScene
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CAS No. 287172-61-6
Cat. No. CS-0020142
Purity≥97%
MDL No.MFCD01940424

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride|CS-0020142

Structure of 287172-61-6

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General Information

CAS No. 287172-61-6
Cat. No. CS-0020142
Purity ≥97%
MDL No. MFCD01940424
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClF₂O₂S
Molecular Weight 291.50
Synonym(s) 5-Bromo-2,4-difluorobenzenesulfonyl chloride
SMILES O=S(C1=CC(Br)=C(F)C=C1F)(Cl)=O

Description

5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride is a fluorinated sulfonyl chloride featuring orthogonal reactivity and enhanced electrophilicity. This bench-stable reagent integrates readily into synthetic pathways requiring selective sulfonamide formation under mild conditions. Its electron-deficient aromatic core facilitates efficient coupling with nucleophiles while maintaining stability during handling.

Application

5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride serves as a versatile building block for the synthesis of sulfonamide-containing pharmaceutical intermediates. Its reactivity is enabled by the electrophilic sulfonyl chloride group, which readily undergoes nucleophilic substitution with amines under mild conditions. The presence of bromo and difluoro substituents provides orthogonal functionalization potential and enhances metabolic stability in downstream applications. This compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns and process-scale syntheses.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

TPSA 34.14
LogP 2.6548
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride

CAS No. 287172-61-6

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