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CS-W001157 4
Total: USD 88.00

5-Hydroxy-6-methylpyrimidine-4-carboxylic acid

  • CAS No. 2869955-58-6

  • Cat. No. CS-0634592
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Hydroxy-6-methylpyrimidine-4-carboxylic acid|CS-0634592

Structure of 2869955-58-6

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General Information

  • CAS No. 2869955-58-6
  • Cat. No. CS-0634592
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₃
  • Molecular Weight 154.12
  • Synonym(s) None
  • SMILES O=C(C1=NC=NC(C)=C1O)O

Description

5-Hydroxy-6-methylpyrimidine-4-carboxylic acid features a pyrimidine core bearing a hydroxyl group at C5, a methyl substituent at C6, and a carboxylic acid at C4. This arrangement delivers a polar, electron-deficient scaffold suitable for bioconjugation and medicinal chemistry applications. The molecule exhibits bench-stable handling characteristics and integrates readily into diverse synthetic pathways.

Application

5-Hydroxy-6-methylpyrimidine-4-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling access to pyrimidine-based scaffolds prevalent in medicinal chemistry. Its orthogonal functional groups—phenolic hydroxyl, methyl, and carboxylic acid—facilitate diverse transformations including amidation, esterification, and metal-catalyzed coupling reactions. The compound exhibits good bench stability and is amenable to purification via recrystallization or chromatography, supporting its use in iterative synthetic sequences and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   83.31
  • LogP   0.18882
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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