Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

6-Hydroxy-3-nitro-2-picoline

  • CAS No. 28489-45-4

  • Cat. No. CS-W016274
  • Purity≥98%
  • MDL No.MFCD00092010

*For research and further manufacturing use only, not for direct human use.

6-Hydroxy-3-nitro-2-picoline|CS-W016274

Structure of 28489-45-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 28489-45-4
  • Cat. No. CS-W016274
  • Purity ≥98%
  • MDL No. MFCD00092010
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₃
  • Molecular Weight 154.13
  • Synonym(s) 6-methyl-5-nitropyridin-2-ol
  • SMILES CC1=NC(O)=CC=C1[N+]([O-])=O

Description

6-Hydroxy-3-nitro-2-picoline features a hydroxyl group at the 6-position and a nitro substituent at the 3-position on a picoline core, enabling dual reactivity. This electron-deficient heterocycle integrates readily into synthetic sequences requiring polar functional handles. The molecule exhibits enhanced solubility in aqueous and protic solvents, facilitating use in medicinal chemistry and process development workflows under standard conditions.

Application

6-Hydroxy-3-nitro-2-picoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the hydroxyl group and facilitating subsequent derivatization via etherification or esterification. Its ortho-nitro substitution enhances electrophilic reactivity, supporting regioselective transformations. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • KARO BIO AB; ELSY, David Patent: WO2005/42464 A1, 2005 ; Location in patent: Page/Page column 33 ; WO 2005/042464 A1
  • Route2

    References

    • Hartz, Richard A.; Ahuja, Vijay T.; Schmitz, William D.; Molski, Thaddeus F.; Mattson, Gail K.; Lodge, Nicholas J.; Bronson, Joanne J.; Macor, John E. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1890 - 1894
  • Route3
    • null|null
      109-06-8
    • ~%
    • In-stock
      6-Hydroxy-3-nitro-2-picoline|CS-W016274
      28489-45-4

    References

    • Parker; Shive Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   76.26
  • LogP   1.00382
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 6-Hydroxy-3-nitro-2-picoline sigma6-Hydroxy-3-nitro-2-picoline manufacturer6-Hydroxy-3-nitro-2-picoline price6-Hydroxy-3-nitro-2-picoline structure6-Hydroxy-3-nitro-2-picoline SDSbuy 6-Hydroxy-3-nitro-2-picoline6-Hydroxy-3-nitro-2-picoline supplier6-Hydroxy-3-nitro-2-picoline uses6-Hydroxy-3-nitro-2-picoline molecular weightprice of 6-Hydroxy-3-nitro-2-picoline6-Hydroxy-3-nitro-2-picoline chemical name formula of 6-Hydroxy-3-nitro-2-picoline
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label