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CS-W001157 4
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2-(Pyridin-4-yl)acetic acid

  • CAS No. 28356-58-3

  • Cat. No. CS-0046227
  • Purity≥97%
  • MDL No.MFCD03701446

*For research and further manufacturing use only, not for direct human use.

2-(Pyridin-4-yl)acetic acid|CS-0046227

Structure of 28356-58-3

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General Information

  • CAS No. 28356-58-3
  • Cat. No. CS-0046227
  • Purity ≥97%
  • MDL No. MFCD03701446
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) pyridin-4-ylacetic acid
  • SMILES O=C(O)CC1=CC=NC=C1

Description

2-(Pyridin-4-yl)acetic acid features a pyridine ring directly linked to an acetic acid side chain, delivering a robust heteroaromatic scaffold with enhanced solubility and polarity. This structural motif enables direct incorporation into bioactive molecules, serving as a key building block in medicinal chemistry and ligand design.

Application

2-(Pyridin-4-yl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through its pendant carboxylic acid and electron-deficient pyridine moiety. The molecule facilitates efficient amide bond formation, metal-catalyzed coupling reactions, and conjugation strategies due to its bench-stable nature and favorable functional group tolerance. Its structure supports integration into diverse heterocyclic scaffolds and drug-like architectures, making it a reliable intermediate for API development and target-oriented synthesis.

Synthesis

  • Route1
    • null|null
      35081-79-9
    • ~89%
    • In-stock
      2-(Pyridin-4-yl)acetic acid|CS-0046227
      28356-58-3

    References

    • Matloubi Moghaddam; Ghaffarzadeh Synthetic Communications, 2001 , vol. 31, # 2 p. 317 - 321
  • Route2
    • 1-(Pyridin-4-yl)ethanone  Imatinib Impurity|CS-0167015
      1122-54-9
    • ~%
    • In-stock
      2-(Pyridin-4-yl)acetic acid|CS-0046227
      28356-58-3

    References

    • Malan; Dean Journal of the American Chemical Society, 1947 , vol. 69, p. 1797
  • Route3
    • null|null
      108-89-4
    • null|null
      124-38-9
    • ~%
    • In-stock
      2-(Pyridin-4-yl)acetic acid|CS-0046227
      28356-58-3

    References

    • Headley, George W.; O'Leary, Marion H. Journal of the American Chemical Society, 1990 , vol. 112, # 5 p. 1894 - 1896

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.7087
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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