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CS-W001157 4
Total: USD 88.00

2-Chloro-N-(hydroxymethyl)acetamide

  • CAS No. 2832-19-1

  • Cat. No. CS-0147071
  • Molecule weight123.54
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloro-N-(hydroxymethyl)acetamide|CS-0147071

Structure of 2832-19-1

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General Information

  • CAS No. 2832-19-1
  • Cat. No. CS-0147071
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₆ClNO₂
  • Molecular Weight 123.54
  • Synonym(s) N-Methylolchloroacetamide
  • SMILES OCNC(CCl)=O

Description

2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction).

Synthesis

  • Route1

    References

    • Einhorn; Mauermayer Justus Liebigs Annalen der Chemie, 1905 , vol. 343, p. 290

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   -0.7088
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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