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rel-((6S,8aS)-Hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-6-yl)methanol

  • CAS No. 2820537-05-9

  • Cat. No. CS-0613746
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

rel-((6S,8aS)-Hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-6-yl)methanol|CS-0613746

Structure of 2820537-05-9

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General Information

  • CAS No. 2820537-05-9
  • Cat. No. CS-0613746
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₂
  • Molecular Weight 157.21
  • Synonym(s) None
  • SMILES [H][C@]12COCCN1[C@H](CO)CC2

Description

This rel-((6S,8aS)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-6-yl)methanol features a stereochemically defined heterocyclic scaffold with a pendant hydroxymethyl group, enabling direct incorporation into chiral building blocks. The bicyclic core exhibits enhanced stability and solubility under standard reaction conditions, facilitating efficient derivatization in synthetic sequences.

Application

rel-((6S,8aS)-Hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-6-yl)methanol serves as a versatile chiral building block for the synthesis of bioactive heterocycles. Its stable pyrrolidine-oxazine core enables efficient functionalization at the C6 position, facilitating amide bond formation and reductive amination. The molecule exhibits excellent bench stability and compatibility with standard purification methods, making it suitable for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.7
  • LogP   -0.1581
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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