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Structure of 28165-66-4
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3-Bromo-5-fluoro-2-hydroxybenzonitrile features a trifunctional aromatic core with bromine, fluorine, and hydroxyl groups positioned ortho and para to the nitrile. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and serves as a building block for bioactive heterocycles and functional materials.
3-Bromo-5-fluoro-2-hydroxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its strategic substitution pattern—bromine for cross-coupling, fluorine for metabolic stability, hydroxyl for derivatization, and nitrile for further functionalization—facilitates diverse transformations under standard reaction conditions. The compound exhibits good bench stability and is compatible with palladium-catalyzed coupling reactions, making it a reliable scaffold for targeted molecular design.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Lot numbers can be found on the outside label of a product: