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1,3-Dibromo-2-methylpropane

  • CAS No. 28148-04-1

  • Cat. No. CS-0154074
  • Purity≥97%
  • MDL No.MFCD18909351

*For research and further manufacturing use only, not for direct human use.

1,3-Dibromo-2-methylpropane|CS-0154074

Structure of 28148-04-1

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General Information

  • CAS No. 28148-04-1
  • Cat. No. CS-0154074
  • Purity ≥97%
  • MDL No. MFCD18909351
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈Br₂
  • Molecular Weight 215.91
  • Synonym(s) 1,3-dibromo-2-methyl-propane
  • SMILES CC(CBr)CBr

Description

1,3-Dibromo-2-methylpropane features a linear carbon backbone with bromine atoms at terminal positions and a methyl group on the central carbon. This structure enables efficient coupling reactions in synthetic workflows, offering high reactivity under standard conditions. The molecule's steric profile enhances selectivity in nucleophilic substitution processes, facilitating clean functionalization of heteroatoms.

Application

1,3-Dibromo-2-methylpropane serves as a versatile bifunctional alkylating agent, enabling efficient synthesis of cyclic ethers and heterocyclic scaffolds. Its stability under ambient conditions and compatibility with diverse functional groups facilitate straightforward incorporation into complex molecular architectures. The molecule functions effectively in nucleophilic substitution reactions, particularly for constructing five- and six-membered rings via intramolecular cyclization, offering reliable access to key intermediates in synthetic organic chemistry workflows.

Synthesis

  • Route1

    References

    • Westerbeek, Alja; Van Leeuwen, Jan G.E.; Szymanski, Wiktor; Feringa, Ben L.; Janssen, Dick B. Tetrahedron, 2012 , vol. 68, # 37 p. 7645 - 7650
  • Route2
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      1458-98-6
    • ~%
    • In-stock
      1,3-Dibromo-2-methylpropane|CS-0154074
      28148-04-1

    References

    • Brewster Journal of the American Chemical Society, 1951 , vol. 73, p. 366,368
  • Route3
    • null|null
      594-34-3
    • ~%
    • In-stock
      1,3-Dibromo-2-methylpropane|CS-0154074
      28148-04-1

    References

    • Faworsdi Justus Liebigs Annalen der Chemie, 1907 , vol. 354, p. 362 Chem. Zentralbl., 1908 , vol. 79, # I p. 1041

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.4123
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   2

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