Lot numbers can be found on the outside label of a product:
4-Chloro-4'-hydroxybiphenyl
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CAS No. 28034-99-3
- Cat. No. CS-0193318
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 28034-99-3
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General Information
- CAS No. 28034-99-3
- Cat. No. CS-0193318
- Purity ≥98%
- MDL No. None
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₉ClO
- Molecular Weight 204.65
- Synonym(s) 4'-Chlorobiphenyl-4-ol
- SMILES C1=C(C=CC(=C1)Cl)C2=CC=C(C=C2)O
Description
4-Chloro-4'-hydroxybiphenyl features a hydroxyl group flanked by a chlorinated aryl ring, enabling direct incorporation into coupling reactions. This electron-deficient scaffold supports efficient functionalization in synthetic organic chemistry and serves as a key intermediate in pharmaceutical and agrochemical development.
Application
4-Chloro-4'-hydroxybiphenyl serves as a versatile building block in medicinal chemistry and materials science, enabling efficient Suzuki-Miyaura coupling due to its compatible aryl halide and phenolic functional groups. The molecule exhibits excellent bench stability and facilitates orthogonal reactivity in multi-step syntheses, with the hydroxyl group readily employed for derivatization or protection. Its structure provides access to biologically relevant biphenyl scaffolds and functionalized aromatic systems commonly found in pharmaceutical intermediates and organic semiconductors.
Synthesis
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Route1
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106-41-2 -
In-stock
1679-18-1 - ~10%
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In-stock
28034-99-3
References
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Tong, Jinhui; Wang, Haiyan; Cai, Xiaodong; Zhang, Qianping; Ma, Hengchang; Lei, Ziqiang Applied Organometallic Chemistry, 2014 , vol. 28, # 2 p. 95 - 100
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References
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Ishikawa, Shunpei; Manabe, Kei Tetrahedron, 2010 , vol. 66, # 1 p. 297 - 303
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Route3
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57396-87-9
- ~%
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In-stock
28034-99-3
References
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Savoy Pr. Louisiana Acad. Sci., 1947 , vol. 10, p. 205,206
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07,GHS08,GHS09
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Signal Word : Warning
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H315-H319-H350-H373-H410
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Precautionary Statements : P260-P264-P273-P280-P302+P352-P362+P364-P391-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 20.23
- LogP 3.7126
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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