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CS-W001157 4
Total: USD 88.00

5-Chlorobenzofuran-2(3H)-one

  • CAS No. 28033-47-8

  • Cat. No. CS-0166883
  • Purity≥96%
  • MDL No.MFCD09842447

*For research and further manufacturing use only, not for direct human use.

5-Chlorobenzofuran-2(3H)-one|CS-0166883

Structure of 28033-47-8

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General Information

  • CAS No. 28033-47-8
  • Cat. No. CS-0166883
  • Purity ≥96%
  • MDL No. MFCD09842447
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C1OC2=CC=C(Cl)C=C2C1

Description

5-Chlorobenzofuran-2(3H)-one is a heterocyclic ketone featuring a chlorinated benzofuran core, offering enhanced stability and solubility in polar organic solvents. This scaffold serves as a key intermediate in the synthesis of bioactive molecules, particularly in medicinal chemistry and agrochemical development.

Application

5-Chlorobenzofuran-2(3H)-one serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocyclic scaffolds. Its electrophilic carbonyl and halogen substituents facilitate palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis and scale-up in API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.8015
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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