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2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran

  • CAS No. 27943-46-0

  • Cat. No. CS-0036235
  • Molecule weight168.23
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran|CS-0036235

Structure of 27943-46-0

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General Information

  • CAS No. 27943-46-0
  • Cat. No. CS-0036235
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆O₂
  • Molecular Weight 168.23
  • Synonym(s) 2-Methyl-3-butyn-2-yl 2-tetrahydropyranyl ether
  • SMILES C#CC(C)(C)OC1CCCCO1

Description

This tetrahydro-2H-pyran derivative features a methylbutynyl ether handle enabling efficient coupling in synthetic workflows. The alkyne moiety supports click chemistry applications, while the pyran ring provides stability and solubility in organic media. Designed for modular synthesis, it integrates readily into complex molecular architectures under standard conditions.

Application

2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized tetrahydropyran scaffolds. The propargylic ether functionality offers robust stability under standard reaction conditions and facilitates selective transformations via Sonogashira coupling or acid-catalyzed cyclization. Its compatibility with diverse protecting group strategies and broad functional group tolerance make it ideal for iterative synthesis in medicinal chemistry and natural product applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   1.9414
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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