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CS-W001157 4
Total: USD 88.00

3,6-Dichloropyridazin-4-ol

  • CAS No. 2779-81-9

  • Cat. No. CS-0097969
  • Molecule weight164.98
  • Purity≥97%
  • MDL No.MFCD04971276

*For research and further manufacturing use only, not for direct human use.

3,6-Dichloropyridazin-4-ol|CS-0097969

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General Information

  • CAS No. 2779-81-9
  • Cat. No. CS-0097969
  • Purity ≥97%
  • MDL No. MFCD04971276
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Cl₂N₂O
  • Molecular Weight 164.98
  • Synonym(s) 3,6-Dichloropyridazin-4-ol, 3,6-Dichloro-4-hydroxy-1,2-diazine
  • SMILES OC1=CC(Cl)=NN=C1Cl

Description

3,6-Dichloropyridazin-4-ol is a bench-stable heterocyclic building block featuring two chlorine substituents at electron-deficient positions. This configuration enables direct functionalization in late-stage diversification, particularly in medicinal chemistry and agrochemical synthesis. The hydroxyl group enhances solubility and serves as a handle for derivatization under mild conditions.

Application

3,6-Dichloropyridazin-4-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution. Its dichloro functionality offers orthogonal reactivity for sequential derivatization, while the phenolic hydroxyl group enhances solubility and facilitates downstream functionalization. The compound exhibits excellent bench stability and is compatible with standard reaction conditions, making it ideal for scalable synthesis of kinase inhibitors and other bioactive molecules.

Synthesis

  • Route1

    References

    • Schoenbeck,R.; Kloimstein,E. Monatshefte fuer Chemie, 1968 , vol. 99, p. 15 - 81 Full Text View citing articles Show Details Eichenberger et al. Helvetica Chimica Acta, 1956 , vol. 39, p. 1755,1762

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   1.489
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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