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CS-W001157 4
Total: USD 88.00

H-Gly-Gly-OMe.HCl

  • CAS No. 2776-60-5

  • Cat. No. CS-0150654
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

H-Gly-Gly-OMe.HCl|CS-0150654

Structure of 2776-60-5

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General Information

  • CAS No. 2776-60-5
  • Cat. No. CS-0150654
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁ClN₂O₃
  • Molecular Weight 182.61
  • Synonym(s) Methyl 2-(2-aminoacetamido)acetate hydrochloride
  • SMILES COC(CNC(CN)=O)=O.Cl

Description

H-Gly-Gly-OMe.HCl delivers a stable, moisture-tolerant dipeptide methyl ester featuring a C-terminal methoxy group and N-terminal protonated amine. This bench-stable derivative enables direct incorporation into peptide coupling sequences without additional activation steps.

Application

H-Gly-Gly-OMe·HCl serves as a stable, bench-ready dipeptide building block for peptide synthesis and medicinal chemistry applications. The N-terminal amine is protected as a hydrochloride salt, enhancing solubility and handling stability. It readily participates in standard coupling reactions with minimal epimerization, enabling efficient assembly of longer peptides and peptidomimetics. The C-terminal methyl ester facilitates direct amidation or reduction to the corresponding alcohol.

Synthesis

  • Route1
    • null|null
      53487-98-2
    • ~93%
    • In-stock
      H-Gly-Gly-OMe.HCl|CS-0150654
      2776-60-5

    References

    • Voelter; Altenburg 1983 , vol. NO. 10, p. 1641 - 1655
  • Route2
    • null|null
      67-56-1
    • In-stock
      Glycylglycine|CS-0015211
      556-50-3
    • ~90%
    • In-stock
      H-Gly-Gly-OMe.HCl|CS-0150654
      2776-60-5

    References

    • Prasad, Puja; Khan, Imran; Kondaiah, Paturu; Chakravarty, Akhil R. Chemistry - A European Journal, 2013 , vol. 19, # 51 p. 17445 - 17455
  • Route3

    References

    • Ducatel, Helene; Van Nhien, Albert Nguyen; Postel, Denis Tetrahedron Asymmetry, 2008 , vol. 19, # 1 p. 67 - 81

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   81.42
  • LogP   -1.3439
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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