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Cis-cyclooctane-1,2-diol

  • CAS No. 27607-33-6

  • Cat. No. CS-0160249
  • Purity≥98%
  • MDL No.MFCD00134226
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Cis-cyclooctane-1,2-diol|CS-0160249

Structure of 27607-33-6

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Description

Cis-cyclooctane-1,2-diol features a rigid, strained cyclooctane backbone with adjacent hydroxyl groups in a cis configuration. This stereochemistry enhances its solubility in polar solvents and facilitates selective transformations in synthetic applications. The molecule exhibits enhanced reactivity at the diol site due to geometric constraints, enabling efficient use in chiral auxiliary design and metal-catalyzed coupling processes.

Application

Cis-cyclooctane-1,2-diol serves as a valuable synthon in stereoselective synthesis, enabling controlled dihydroxylation pathways and facilitating the construction of complex cyclic architectures. Its cis configuration provides predictable stereochemical outcomes in ring-functionalization reactions, while its bench-stable nature supports straightforward handling and purification. The molecule functions effectively in oxidation-sensitive transformations and serves as a key intermediate for accessing bioactive heterocyclic scaffolds through selective deprotection or cyclization protocols.

General Information

  • CAS No. 27607-33-6
  • Cat. No. CS-0160249
  • Purity ≥98%
  • MDL No. MFCD00134226
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆O₂
  • Molecular Weight 144.21
  • Synonym(s) cis-1,2-Cyclooctanediol
  • SMILES O[C@H]1[C@@H](O)CCCCCC1

Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.0624
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group :
Hazard Statements : H303-H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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