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CS-W001157 4
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(R)-4-Isopropyl-2-(pyrimidin-2-yl)-4,5-dihydrooxazole

  • CAS No. 2757082-66-7

  • Cat. No. CS-0179438
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-4-Isopropyl-2-(pyrimidin-2-yl)-4,5-dihydrooxazole|CS-0179438

Structure of 2757082-66-7

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General Information

  • CAS No. 2757082-66-7
  • Cat. No. CS-0179438
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃N₃O
  • Molecular Weight 191.23
  • Synonym(s) None
  • SMILES CC(C)[C@@H]1COC(C2=NC=CC=N2)=N1

Description

(R)-4-Isopropyl-2-(pyrimidin-2-yl)-4,5-dihydrooxazole is a chiral heterocyclic scaffold featuring a pyrimidine moiety and an isopropyl group at the 4-position. This bench-stable compound integrates readily into medicinal chemistry campaigns, offering a rigid, electron-deficient platform for targeted molecular design in kinase inhibitor development.

Application

(R)-4-Isopropyl-2-(pyrimidin-2-yl)-4,5-dihydrooxazole serves as a versatile chiral building block in medicinal chemistry, enabling stereoselective synthesis of complex heterocyclic scaffolds. Its pyrimidine moiety offers robust functional group tolerance and compatibility with standard coupling reactions, while the dihydrooxazole ring provides a stable, bench-accessible platform for further derivatization. This compound facilitates efficient construction of pharmaceutically relevant frameworks through mild, operationally simple transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   47.37
  • LogP   1.278
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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