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CS-W001157 4
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2-(Benzofuran-3-yl)ethanamine

  • CAS No. 27404-31-5

  • Cat. No. CS-W019375
  • Molecule weight161.20
  • Purity≥95%
  • MDL No.MFCD08271905

*For research and further manufacturing use only, not for direct human use.

2-(Benzofuran-3-yl)ethanamine|CS-W019375

Structure of 27404-31-5

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General Information

  • CAS No. 27404-31-5
  • Cat. No. CS-W019375
  • Purity ≥95%
  • MDL No. MFCD08271905
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO
  • Molecular Weight 161.20
  • Synonym(s) 3-Benzofuranethanamine
  • SMILES NCCC1=COC2=CC=CC=C12

Description

2-(Benzofuran-3-yl)ethanamine features a benzofuran scaffold linked to an ethanamine side chain, delivering a rigid, electron-rich heteroaromatic framework. This structure integrates readily into bioactive molecule design, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Application

2-(Benzofuran-3-yl)ethanamine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to biologically relevant scaffolds. Its pendant amine group facilitates straightforward derivatization via amidation, alkylation, or reductive amination, while the benzofuran core offers robust stability and favorable pharmacophore characteristics. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for medicinal chemistry campaigns and process development.

Synthesis

  • Route1

    References

    • Merck and Co., Inc. Patent: US4835276 A1, 1989 ;
  • Route2

    References

    • Huff; Anderson; Baldwin; Clineschmidt; Guare; Lotti; Pettibone; Randall; Vacca Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1756 - 1759

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.16
  • LogP   1.934
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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