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CS-W001157 4
Total: USD 88.00

Indolizine

  • CAS No. 274-40-8

  • Cat. No. CS-0155664
  • Purity≥95%
  • MDL No.MFCD00030189

*For research and further manufacturing use only, not for direct human use.

Indolizine|CS-0155664

Structure of 274-40-8

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General Information

  • CAS No. 274-40-8
  • Cat. No. CS-0155664
  • Purity ≥95%
  • MDL No. MFCD00030189
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N
  • Molecular Weight None
  • Synonym(s) Pyrrolo[1,2-a]pyridine
  • SMILES C1=CC2=CC=CN2C=C1

Description

Indolizine delivers a rigid, electron-rich heterocyclic scaffold ideal for conjugated systems. This fused bicyclic core integrates seamlessly into photoresponsive materials and donor-acceptor architectures, offering enhanced stability under ambient conditions. Its planar geometry supports efficient π-overlap in molecular electronics and enables selective functionalization at the 1- and 7-positions.

Application

Indolizine serves as a versatile heterocyclic building block in synthetic organic chemistry, enabling efficient access to complex nitrogen-containing scaffolds. Its inherent stability and compatibility with standard functional groups facilitate diverse transformations, including cycloadditions and metal-catalyzed couplings. The scaffold functions effectively in the construction of bioactive molecules and natural product analogs, offering reliable reactivity for both academic and industrial applications.

Synthesis

  • Route1
    • null|null
      2859-68-9
    • ~%
    • In-stock
      Indolizine|CS-0155664
      274-40-8

    References

    • Boekelheide; Windgassen Journal of the American Chemical Society, 1959 , vol. 81, p. 1456,1459
  • Route2
    • null|null
      35469-62-6
    • ~48%
    • In-stock
      Indolizine|CS-0155664
      274-40-8

    References

    • Ohsawa, Akio; Kawaguchi, Takayuki; Igeta, Hiroshi Journal of Organic Chemistry, 1982 , vol. 47, # 18 p. 3497 - 3503
  • Route3
    • null|null
      167320-18-5
    • ~37%
    • In-stock
      Indolizine|CS-0155664
      274-40-8
    • Indole, ≥99%|CS-1268948
      120-72-9

    References

    • Xiang, Yi-Bin; Drenkard, Susanne; Baumann, Karl; Hickey, Deirdre; Eschenmoser, Albert Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2209 - 2250

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   4.41
  • LogP   1.9393
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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