Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid

  • CAS No. 273222-07-4

  • Cat. No. CS-0626856
  • Molecule weight373.35
  • Purity≥95%
  • MDL No.MFCD01860710

*For research and further manufacturing use only, not for direct human use.

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid|CS-0626856

Structure of 273222-07-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 273222-07-4
  • Cat. No. CS-0626856
  • Purity ≥95%
  • MDL No. MFCD01860710
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₁₇F₂NO₄
  • Molecular Weight 373.35
  • Synonym(s) None
  • SMILES O=C(N1[C@H](CC(F)(C1)F)C(O)=O)OCC2C3=CC=CC=C3C4=CC=CC=C42

Description

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid is a chiral building block featuring a sterically constrained pyrrolidine core with a fluorenylmethyl carbamate protecting group. This configuration enables reliable incorporation into peptide sequences under standard coupling conditions. The 4,4-difluoro substitution enhances metabolic stability and modulates conformational flexibility. The fluorenylmethyl moiety facilitates efficient purification via crystallization or chromatography.

Application

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid serves as a valuable chiral building block in peptide synthesis, leveraging the robustness of Fmoc protection. The 4,4-difluoropyrrolidine moiety imparts enhanced metabolic stability and conformational rigidity, facilitating structural modulation in bioactive peptides. Its bench-stable nature and compatibility with standard coupling protocols enable efficient incorporation into complex scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   66.84
  • LogP   3.7297
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 273222-07-4 sigma273222-07-4 manufacturer273222-07-4 price273222-07-4 structure273222-07-4 SDSbuy 273222-07-4273222-07-4 supplier273222-07-4 uses273222-07-4 molecular weightprice of 273222-07-4273222-07-4 chemical name formula of 273222-07-4
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label