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CS-W001157 4
Total: USD 88.00

Oxazolo[4,5-b]pyridine

  • CAS No. 273-97-2

  • Cat. No. CS-0044085
  • Molecule weight120.11
  • Purity≥97%
  • MDL No.MFCD13175183

*For research and further manufacturing use only, not for direct human use.

Oxazolo[4,5-b]pyridine|CS-0044085

Structure of 273-97-2

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General Information

  • CAS No. 273-97-2
  • Cat. No. CS-0044085
  • Purity ≥97%
  • MDL No. MFCD13175183
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄N₂O
  • Molecular Weight 120.11
  • Synonym(s) 4-azabenzoxazole
  • SMILES C12=NC=CC=C1OC=N2

Description

Oxazolo[4,5-b]pyridine delivers a rigid, electron-deficient heterocyclic scaffold ideal for constructing bioactive molecules. This fused system combines nitrogen-rich functionality with planar geometry, enabling strong π-stacking interactions and enhanced metabolic stability in pharmaceutical applications.

Application

Oxazolo[4,5-b]pyridine serves as a privileged heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and favorable pharmacokinetic properties. Its fused tricyclic structure enables robust functionalization at multiple positions, facilitating diverse downstream modifications. The core exhibits excellent bench stability, tolerates common reaction conditions, and functions effectively in cross-coupling and nucleophilic substitution processes, making it a valuable building block for the synthesis of targeted small-molecule libraries and advanced API intermediates.

Synthesis

  • Route1
    • In-stock
      2-Amino-3-hydroxypyridine|CS-W007794
      16867-03-1
    • null|null
      122-51-0
    • ~97%
    • In-stock
      Oxazolo[4,5-b]pyridine|CS-0044085
      273-97-2

    References

    • Hojati, Seyedeh Fatemeh; Maleki, Behrooz; Beykzadeh, Zahra Monatshefte fur Chemie, 2011 , vol. 142, # 1 p. 87 - 91
  • Route2
    • In-stock
      2-Amino-3-hydroxypyridine|CS-W007794
      16867-03-1
    • null|null
      149-73-5
    • ~81%
    • In-stock
      Oxazolo[4,5-b]pyridine|CS-0044085
      273-97-2

    References

    • Hojati, Seyedeh Fatemeh; Maleki, Behrooz; Beykzadeh, Zahra Monatshefte fur Chemie, 2011 , vol. 142, # 1 p. 87 - 91

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.92
  • LogP   1.2228
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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