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CS-W001157 4
Total: USD 88.00

1H-Imidazo[4,5-b]pyrazine

  • CAS No. 273-94-9

  • Cat. No. CS-W021326
  • Purity≥98%
  • MDL No.MFCD08669465

*For research and further manufacturing use only, not for direct human use.

1H-Imidazo[4,5-b]pyrazine|CS-W021326

Structure of 273-94-9

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General Information

  • CAS No. 273-94-9
  • Cat. No. CS-W021326
  • Purity ≥98%
  • MDL No. MFCD08669465
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₄
  • Molecular Weight 120.11
  • Synonym(s) None
  • SMILES C12=NC=CN=C1N=CN2

Description

1H-Imidazo[4,5-b]pyrazine is a nitrogen-rich heterocycle featuring fused imidazole and pyrazine rings, offering enhanced planarity and electron-deficient character. This structural motif integrates readily into pharmaceutical scaffolds and functional materials, providing robust stability under standard conditions.

Application

1H-Imidazo[4,5-b]pyrazine serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling the construction of bioactive molecules through established coupling and functionalization protocols. Its planar, electron-deficient core exhibits favorable stability and solubility profiles, facilitating purification and integration into complex synthetic sequences. The system functions as a key building block for kinase inhibitors and other pharmacologically relevant scaffolds, with demonstrated compatibility across standard reaction conditions.

Synthesis

  • Route1
    • In-stock
      Pyrazine-2,3-diamine|CS-W003425
      13134-31-1
    • null|null
      122-51-0
    • ~%
    • In-stock
      1H-Imidazo[4,5-b]pyrazine|CS-W021326
      273-94-9

    References

    • Muehlmann; Day Journal of the American Chemical Society, 1956 , vol. 78, p. 242

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.46
  • LogP   0.3529
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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