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CS-W001157 4
Total: USD 88.00

Piazthiole

  • CAS No. 273-13-2

  • Cat. No. CS-W017754
  • Purity≥97%
  • MDL No.MFCD00005809

*For research and further manufacturing use only, not for direct human use.

Piazthiole|CS-W017754

Structure of 273-13-2

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General Information

  • CAS No. 273-13-2
  • Cat. No. CS-W017754
  • Purity ≥97%
  • MDL No. MFCD00005809
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄N₂S
  • Molecular Weight None
  • Synonym(s) None
  • SMILES C1=CC=CC2=NSN=C12

Description

Piazthiole features a fused heterocyclic core combining pyrrole and thiazole rings, delivering enhanced electron delocalization and stability. This scaffold serves as a key pharmacophore in bioactive molecule design, enabling efficient integration into diverse synthetic architectures through its reactive sulfur and nitrogen sites.

Application

Piazthiole serves as a versatile heterocyclic building block in synthetic organic chemistry, enabling efficient access to thiazole and related scaffold architectures. Its inherent stability under standard reaction conditions facilitates functional group tolerance and compatibility with common coupling protocols. The molecule functions as a key intermediate in the synthesis of bioactive compounds, particularly those requiring sulfur-containing heterocycles, and is valued for its predictable reactivity in nucleophilic substitution and metal-catalyzed transformations.

Synthesis

  • Route1
    • null|null
      95-54-5
    • ~95%
    • In-stock
      Piazthiole|CS-W017754
      273-13-2

    References

    • Belen'kaya, I. A.; Shulla, T. A. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 11 p. 1303 - 1307 Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 11 p. 1555 - 1558
  • Route2
    • null|null
      480-96-6
    • ~7%
    • In-stock
      Piazthiole|CS-W017754
      273-13-2

    References

    • Jorgensen, K. A.; Shabana, R.; Scheibye, S.; Lawesson, S.-O. Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 3 p. 247 - 254
  • Route3
    • null|null
      4377-90-6
    • ~48%
    • In-stock
      Piazthiole|CS-W017754
      273-13-2

    References

    • Bryce, Martin R. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 11 p. 2591 - 2593

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.6913
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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