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CS-W001157 4
Total: USD 88.00

3-(Piperidin-1-yl)phenol

  • CAS No. 27292-50-8

  • Cat. No. CS-0019020
  • Purity≥97%
  • MDL No.MFCD00053001

*For research and further manufacturing use only, not for direct human use.

3-(Piperidin-1-yl)phenol|CS-0019020

Structure of 27292-50-8

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General Information

  • CAS No. 27292-50-8
  • Cat. No. CS-0019020
  • Purity ≥97%
  • MDL No. MFCD00053001
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO
  • Molecular Weight 177.24
  • Synonym(s) 3-PIPERIDINOPHENOL
  • SMILES OC1=CC=CC(N2CCCCC2)=C1

Description

3-(Piperidin-1-yl)phenol features a piperidine ring attached to the phenolic scaffold, delivering enhanced solubility and basicity. This combination enables effective participation in nucleophilic substitutions and facilitates integration into bioactive scaffolds. The molecule exhibits bench-stable handling under standard conditions.

Application

3-(Piperidin-1-yl)phenol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization protocols. Its phenolic hydroxyl group facilitates regioselective derivatization, while the piperidinyl moiety provides a basic nitrogen for salt formation and enhanced solubility. The compound exhibits good bench stability and compatibility with common functional groups, making it suitable for iterative synthesis and scale-up workflows.

Synthesis

  • Route1
    • null|null
      110-89-4
    • null|null
      591-20-8
    • ~89%
    • In-stock
      3-(Piperidin-1-yl)phenol|CS-0019020
      27292-50-8

    References

    • Urgaonkar, Sameer; Verkade, John G. Advanced Synthesis and Catalysis, 2004 , vol. 346, # 6 p. 611 - 616
  • Route2
    • null|null
      110-89-4
    • null|null
      108-43-0
    • ~64%
    • In-stock
      3-(Piperidin-1-yl)phenol|CS-0019020
      27292-50-8

    References

    • Urgaonkar, Sameer; Verkade, John G. Advanced Synthesis and Catalysis, 2004 , vol. 346, # 6 p. 611 - 616
  • Route3
    • null|null
      111-24-0
    • null|null
      591-27-5
    • ~73%
    • In-stock
      3-(Piperidin-1-yl)phenol|CS-0019020
      27292-50-8

    References

    • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; OSCOTEC INC. Patent: WO2005/123054 A1, 2005 ; Location in patent: Page/Page column 31 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   2.3825
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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