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CS-W001157 4
Total: USD 88.00

3-Morpholinophenol

  • CAS No. 27292-49-5

  • Cat. No. CS-0044986
  • Purity≥98%
  • MDL No.MFCD00051675

*For research and further manufacturing use only, not for direct human use.

3-Morpholinophenol|CS-0044986

Structure of 27292-49-5

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General Information

  • CAS No. 27292-49-5
  • Cat. No. CS-0044986
  • Purity ≥98%
  • MDL No. MFCD00051675
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO₂
  • Molecular Weight 179.22
  • Synonym(s) 3-(4-Morpholinyl)Phenol
  • SMILES OC1=CC=CC(N2CCOCC2)=C1

Description

3-Morpholinophenol integrates a morpholine ring directly attached to a phenolic hydroxyl group, delivering enhanced solubility and polarity. This structural combination enables facile derivatization in synthetic transformations, particularly in medicinal chemistry scaffolds where hydrogen bonding capacity and metabolic stability are critical. The compound exhibits bench-stable handling under standard conditions.

Application

3-Morpholinophenol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its phenolic hydroxyl group facilitates direct functionalization or derivatization, while the morpholine ring provides solubility enhancement and favorable pharmacokinetic properties. The molecule exhibits bench stability and compatibility with standard coupling reactions, making it a practical choice for iterative synthesis campaigns.

Synthesis

  • Route1
    • null|null
      26926-56-7
    • ~80%
    • In-stock
      3-Morpholinophenol|CS-0044986
      27292-49-5

    References

    • WO2005/123054 A1, ; Page/Page column 30 ;
  • Route2
    • null|null
      110-91-8
    • null|null
      591-20-8
    • ~93%
    • In-stock
      3-Morpholinophenol|CS-0044986
      27292-49-5

    References

    • Advanced Synthesis and Catalysis, , vol. 346, # 6 p. 611 - 616
  • Route3
    • null|null
      110-91-8
    • null|null
      108-43-0
    • ~96%
    • In-stock
      3-Morpholinophenol|CS-0044986
      27292-49-5

    References

    • Advanced Synthesis and Catalysis, , vol. 346, # 6 p. 611 - 616

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H311
Precautionary Statements : P264-P270-P280-P302+P352-P330-P361+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.7
  • LogP   1.2288
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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