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CS-W001157 4
Total: USD 88.00

1H-Pyrazolo[3,4-b]pyrazine

  • CAS No. 272-60-6

  • Cat. No. CS-0052523
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1H-Pyrazolo[3,4-b]pyrazine|CS-0052523

Structure of 272-60-6

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General Information

  • CAS No. 272-60-6
  • Cat. No. CS-0052523
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₄
  • Molecular Weight 120.11
  • Synonym(s) 4,7-DIAZA-1H-INDAZOLE
  • SMILES N1N=CC2=C1N=CC=N2

Description

1H-Pyrazolo[3,4-b]pyrazine is a nitrogen-rich heterocycle featuring fused pyrazole and pyrazine rings, offering enhanced electron-deficient character. This scaffold integrates readily into pharmaceutical intermediates and functional materials due to its planar geometry and strong π-conjugation. The system exhibits favorable stability under standard bench conditions and serves as a key building block in medicinal chemistry and advanced material design.

Application

1H-Pyrazolo[3,4-b]pyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to fused polycyclic scaffolds. Its well-defined reactivity supports direct functionalization at multiple positions, facilitating diverse substitution patterns under standard coupling conditions. The core exhibits robust bench stability and compatibility with common protecting groups, making it suitable for multi-step synthesis workflows.

Synthesis

  • Route1
    • null|null
      81411-67-8
    • ~54%
    • In-stock
      1H-Pyrazolo[3,4-b]pyrazine|CS-0052523
      272-60-6

    References

    • Kocevar, Marjan; Tisler, Miha; Stanovnik, Branko Heterocycles, 1982 , vol. 19, # 2 p. 339 - 342
  • Route2
    • null|null
      76952-35-7
    • ~%
    • In-stock
      1H-Pyrazolo[3,4-b]pyrazine|CS-0052523
      272-60-6

    References

    • Kocevar, Marjan; Vercek, Bojan; Stanovnik, Branko; Tisler, Miha Monatshefte fuer Chemie, 1982 , vol. 113, p. 731 - 744
  • Route3
    • null|null
      81411-65-6
    • ~%
    • In-stock
      1H-Pyrazolo[3,4-b]pyrazine|CS-0052523
      272-60-6

    References

    • Kocevar, Marjan; Vercek, Bojan; Stanovnik, Branko; Tisler, Miha Monatshefte fuer Chemie, 1982 , vol. 113, p. 731 - 744

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.46
  • LogP   0.3529
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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