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CS-W001157 4
Total: USD 88.00

4-Hydroxybutane-1-sulfonic acid

  • CAS No. 26978-64-3

  • Cat. No. CS-0132130
  • Purity95% (contains <15%H2O)
  • MDL No.MFCD28130072

*For research and further manufacturing use only, not for direct human use.

4-Hydroxybutane-1-sulfonic acid|CS-0132130

Structure of 26978-64-3

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General Information

  • CAS No. 26978-64-3
  • Cat. No. CS-0132130
  • Purity 95% (contains <15%H2O)
  • MDL No. MFCD28130072
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀O₄S
  • Molecular Weight 154.18
  • Synonym(s) 4-Hydroxy-1-butanesulfonic acid
  • SMILES O=S(CCCCO)(O)=O

Description

4-Hydroxybutane-1-sulfonic acid features a hydrophilic sulfonate group paired with a terminal hydroxyl function, enabling versatile solubility and reactivity in aqueous systems. This bifunctional architecture supports applications in synthetic intermediates and chiral auxiliaries where polarity and hydrogen-bonding capacity are critical.

Application

4-Hydroxybutane-1-sulfonic acid serves as a versatile bifunctional building block, enabling efficient synthesis of sulfonated bioactive molecules and polymer intermediates. Its hydroxyl and sulfonic acid groups offer orthogonal reactivity for selective derivatization, while the aliphatic chain provides favorable solubility and metabolic stability. The compound demonstrates excellent bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns and functional material development.

Synthesis

  • Route1

    References

    • King,J.F.; Loosmore,S.M.; Aslam,M. Journal of the American Chemical Society, 1982 , vol. 104, p. 7108
  • Route2
    • 4,4'-Disulfanediylbis(butan-1-ol)|CS-0571759
      30453-20-4
    • ~%
    • In-stock
      4-Hydroxybutane-1-sulfonic acid|CS-0132130
      26978-64-3

    References

    • Doi, Joyce Takahashi; Luehr, Gary W.; Musker, W. Kenneth Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5716 - 5719
  • Route3

    References

    • Helferich,B.; Kleb,K.G. Justus Liebigs Annalen der Chemie, 1960 , vol. 635, p. 91 - 96

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   -0.3533
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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