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2,8-Diazaspiro[4.5]decane-1,3-dione hydrochloride

  • CAS No. 2696-03-9

  • Cat. No. CS-0000529
  • Purity≥95%
  • MDL No.MFCD13185074

*For research and further manufacturing use only, not for direct human use.

2,8-Diazaspiro[4.5]decane-1,3-dione hydrochloride|CS-0000529

Structure of 2696-03-9

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General Information

  • CAS No. 2696-03-9
  • Cat. No. CS-0000529
  • Purity ≥95%
  • MDL No. MFCD13185074
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃ClN₂O₂
  • Molecular Weight 204.65
  • Synonym(s) None
  • SMILES O=C(C12CCNCC1)NC(C2)=O.Cl

Description

This hydrochloride salt of 2,8-diazaspiro[4.5]decane-1,3-dione features a rigid spirocyclic core with two nitrogen atoms positioned for enhanced basicity and solubility. The protonated form improves handling and crystallinity under standard conditions, enabling efficient incorporation into medicinal chemistry campaigns requiring stable, polar heterocyclic scaffolds.

Application

2,8-Diazaspiro[4.5]decane-1,3-dione hydrochloride serves as a rigid, bicyclic scaffold enabling the construction of diverse heterocyclic architectures. Its functionalized diketone core facilitates nucleophilic additions and cyclizations under mild conditions, while the protonated amine centers enhance solubility and chromatographic handling. The compound exhibits bench stability and compatibility with standard synthetic workflows, making it a practical building block for medicinal chemistry campaigns targeting constrained molecular frameworks.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.2
  • LogP   -0.1755
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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