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CS-W001157 4
Total: USD 88.00

4-(4-Chlorophenyl)piperidine

  • CAS No. 26905-02-2

  • Cat. No. CS-W005284
  • Purity≥98%
  • MDL No.MFCD03077010

*For research and further manufacturing use only, not for direct human use.

4-(4-Chlorophenyl)piperidine|CS-W005284

Structure of 26905-02-2

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General Information

  • CAS No. 26905-02-2
  • Cat. No. CS-W005284
  • Purity ≥98%
  • MDL No. MFCD03077010
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄ClN
  • Molecular Weight 195.69
  • Synonym(s) Piperidine, 4-(4-chlorophenyl)-
  • SMILES ClC1=CC=C(C2CCNCC2)C=C1

Description

4-(4-Chlorophenyl)piperidine is a sterically defined piperidine derivative featuring a para-chlorinated phenyl ring. This scaffold integrates a lipophilic aryl moiety with a basic nitrogen center, enabling effective membrane permeability and targeted receptor engagement. The compound serves as a core building block in medicinal chemistry for CNS-active agents and kinase inhibitors.

Application

4-(4-Chlorophenyl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its stable piperidine core exhibits favorable solubility and functional group tolerance, facilitating downstream derivatization via alkylation, acylation, or coupling reactions. The para-chlorophenyl substituent enhances lipophilicity and provides a handle for further functionalization, making this compound well-suited for lead optimization campaigns in CNS-targeted drug discovery.

Synthesis

  • Route1
    • null|null
      30005-58-4
    • ~99%
    • In-stock
      4-(4-Chlorophenyl)piperidine|CS-W005284
      26905-02-2

    References

    • Shell Research Limited Patent: US5489599 A1, 1996 ;
  • Route2

    References

    • 3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W. Patent: WO2014/8197 A1, 2014 ; Location in patent: Page/Page column 113 ;
  • Route3
    • null|null
      143866-70-0
    • ~82%
    • In-stock
      4-(4-Chlorophenyl)piperidine|CS-W005284
      26905-02-2

    References

    • Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.807
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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