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CS-W001157 4
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N-Methylpropiolamide

  • CAS No. 2682-32-8

  • Cat. No. CS-0202683
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-Methylpropiolamide|CS-0202683

Structure of 2682-32-8

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General Information

  • CAS No. 2682-32-8
  • Cat. No. CS-0202683
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅NO
  • Molecular Weight 83.09
  • Synonym(s) None
  • SMILES C#CC(NC)=O

Description

N-Methylpropiolamide features a conjugated alkyne amide structure that enables efficient incorporation into click chemistry workflows. The methyl group enhances solubility and metabolic stability, while the terminal alkyne supports copper-catalyzed azide-alkyne cycloaddition. This reagent combines synthetic versatility with bench-stable handling for bioconjugation and materials applications.

Application

N-Methylpropiolamide serves as a versatile building block in synthetic organic chemistry, enabling efficient access to α,β-unsaturated amides and heterocyclic scaffolds. Its conjugated alkyne functionality facilitates reliable copper-catalyzed cycloadditions and nucleophilic additions, while the N-methyl group enhances stability and solubility. The compound exhibits excellent bench stability and compatibility with common functional groups, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   -0.6344
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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