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CS-W001157 4
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine

  • CAS No. 26581-81-7

  • Cat. No. CS-0168360
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(2,6-Dioxopiperidin-3-yl)phthalimidine|CS-0168360

Structure of 26581-81-7

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General Information

  • CAS No. 26581-81-7
  • Cat. No. CS-0168360
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₂N₂O₃
  • Molecular Weight 244.25
  • Synonym(s) EM-12
  • SMILES O=C(C(N(CC1=C2C=CC=C1)C2=O)CC3)NC3=O

Description

2-(2,6-Dioxopiperidin-3-yl)phthalimidine features a fused phthalimide-piperidinone core with dual carbonyl groups enabling robust conjugation and stability. This scaffold integrates readily into synthetic routes requiring electron-deficient heterocycles, offering high reactivity in amide bond formation and transition metal-catalyzed coupling processes under standard conditions.

Application

2-(2,6-Dioxopiperidin-3-yl)phthalimidine serves as a versatile building block in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds through nucleophilic displacement and cycloaddition reactions. Its dual phthalimide and piperidinedione functionalities offer orthogonal reactivity, facilitating efficient functionalization and incorporation into bioactive molecules. The compound exhibits good bench stability and is amenable to purification by standard chromatographic techniques, supporting reliable use in multi-step synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.48
  • LogP   -0.061
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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