2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide

Name: 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2653-16-9
Cat. No. CS-0011634
Purity≥98%
MDL No.MFCD01026196

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide|CS-0011634

Structure of 2653-16-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 2653-16-9
Cat. No. CS-0011634
Purity ≥98%
MDL No. MFCD01026196
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₉ClN₂O₃
Molecular Weight 228.63
Synonym(s) None
SMILES O=C(N(C1=CC=C([N+]([O-])=O)C=C1)C)CCl

Description

2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide features a chloro-substituted acetyl group paired with a nitroaromatic amine, enabling direct incorporation into synthetic pathways requiring electron-deficient aryl coupling partners. This bench-stable compound facilitates efficient access to functionalized heterocycles and conjugated systems under standard conditions.

Application

2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide serves as a versatile acylating agent in synthetic organic chemistry, enabling efficient introduction of the 2-chloroacetyl group under mild conditions. Its stability and ease of handling make it well-suited for bench-scale applications, particularly in the synthesis of heterocyclic compounds and peptide derivatives. The presence of the electron-withdrawing nitro group enhances electrophilicity at the carbonyl center, facilitating nucleophilic substitution with amines and alcohols. This compound functions reliably in standard coupling protocols and is compatible with diverse functional groups, supporting its use in medicinal chemistry and process development workflows.

Synthesis

Route1
- 79-04-9
- 100-15-2
- ~95%
- In-stock
  
  2653-16-9
References
- Hennessy, Edward J.; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 40 p. 12084 - 12085
Route2
- 4015-58-1
- 100-15-2
- ~%
- In-stock
  
  2653-16-9
References
- Svetkin,Yu.V. J. Gen. Chem. USSR (Engl. Transl.), 1965 , vol. 35, # 5 p. 834 - 836,837 - 839

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P301+P310-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 63.45
LogP 1.7964
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

2653-16-9 sigma2653-16-9 manufacturer2653-16-9 price2653-16-9 structure2653-16-9 SDSbuy 2653-16-92653-16-9 supplier2653-16-9 uses2653-16-9 molecular weightprice of 2653-16-92653-16-9 chemical name formula of 2653-16-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide

CAS No. 2653-16-9

Recommended Products