CRBN ligand-394

Name: CRBN ligand-394
Brand: ChemScene
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CAS No. 2641512-77-6
Cat. No. CS-0928755
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 2641512-77-6

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General Information

CAS No. 2641512-77-6
Cat. No. CS-0928755
Purity ≥98%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₀ClN₃O₂
Molecular Weight 309.79
Synonym(s) None
SMILES Cl.O=C1NC(=O)C(C2=CC=C(C=C2)N3CCNCC3)CC1

Description

This piperidine-dione scaffold integrates a piperazinylphenyl moiety, delivering enhanced solubility and metabolic stability. The hydrochloride salt form ensures excellent crystallinity and handling convenience, enabling seamless incorporation into medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors under standard conditions.

Application

3-(4-(Piperazin-1-yl)phenyl)piperidine-2,6-dione hydrochloride serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide and C–H functionalization reactions. Its piperazine-aryl-piperidinedione architecture provides favorable solubility and metabolic stability, while the hydrochloride salt enhances bench stability and ease of handling. Functions effectively in parallel synthesis campaigns and offers orthogonal reactivity for late-stage derivatization.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 61.44
LogP 1.0382
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Drug Discovery Cancer CDK

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CRBN ligand-394

CAS No. 2641512-77-6

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