5-Bromo-3-(3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropyl)-2-iodo-1H-indole

Name: 5-Bromo-3-(3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropyl)-2-iodo-1H-indole
Brand: ChemScene
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CAS No. 2641451-43-4
Cat. No. CS-0433951
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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5-Bromo-3-(3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropyl)-2-iodo-1H-indole|CS-0433951

Structure of 2641451-43-4

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General Information

CAS No. 2641451-43-4
Cat. No. CS-0433951
Purity ≥97%
MDL No. None
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₉H₃₃BrINOSi
Molecular Weight 646.47
Synonym(s) None
SMILES IC(N1)=C(CC(C)(C)CO[Si](C2=CC=CC=C2)(C(C)(C)C)C3=CC=CC=C3)C4=C1C=CC(Br)=C4

Description

This indole scaffold features a bromo substituent at C5 and an iodo group at C2, enabling sequential cross-coupling reactions. The tert-butyldiphenylsilyl-protected hydroxyl at the 3-position provides orthogonal reactivity and enhanced stability during multistep syntheses. This combination delivers a robust platform for constructing complex heterocyclic architectures in medicinal chemistry and natural product synthesis.

Application

5-Bromo-3-(3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropyl)-2-iodo-1H-indole serves as a versatile building block for the synthesis of complex indole-based scaffolds. The molecule combines a bromo- and iodo-substituted indole core with a silyl-protected hydroxyl group, enabling orthogonal functionalization in multi-step sequences. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient diversification in medicinal chemistry and natural product synthesis workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 25.02
LogP 7.6803
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 7

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Functional Group Organosilicon compounds

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Drug Discovery Cancer KRAS

Key Words

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5-Bromo-3-(3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropyl)-2-iodo-1H-indole

CAS No. 2641451-43-4

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