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CS-W001157 4
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4-(4-Fluorophenyl)pyrrolidin-2-one

  • CAS No. 264122-82-9

  • Cat. No. CS-0101081
  • Purity≥96%
  • MDL No.MFCD03447332

*For research and further manufacturing use only, not for direct human use.

4-(4-Fluorophenyl)pyrrolidin-2-one|CS-0101081

Structure of 264122-82-9

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General Information

  • CAS No. 264122-82-9
  • Cat. No. CS-0101081
  • Purity ≥96%
  • MDL No. MFCD03447332
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀FNO
  • Molecular Weight 179.19
  • Synonym(s) 2-Pyrrolidinone, 4-(4-Fluorophenyl)
  • SMILES O=C1NCC(C2=CC=C(F)C=C2)C1

Description

4-(4-Fluorophenyl)pyrrolidin-2-one features a fluorinated aromatic ring fused to a pyrrolidinone core, delivering enhanced metabolic stability and improved membrane permeability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for CNS-targeted therapeutics and kinase inhibitors.

Application

4-(4-Fluorophenyl)pyrrolidin-2-one serves as a versatile building block in medicinal chemistry, offering a stable, bench-ready scaffold for the synthesis of bioactive molecules. Its pyrrolidinone core enables facile functionalization at C2 and C4 positions, while the 4-fluorophenyl group provides enhanced metabolic stability and favorable pharmacokinetic properties. The compound exhibits excellent functional group tolerance and is compatible with standard coupling, reduction, and cyclization protocols, facilitating efficient access to diverse heterocyclic frameworks and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.4292
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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