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Structure of 26340-58-9
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(E)-4-Chlorobut-2-enoic acid features a conjugated enoic acid system with a chlorine substituent at the C4 position, enabling direct participation in Michael additions and Diels–Alder reactions. The trans geometry stabilizes the double bond, enhancing synthetic utility in building complex molecular architectures under mild conditions.
(E)-4-Chlorobut-2-enoic acid serves as a versatile building block for the synthesis of substituted pyrroles and other heterocyclic scaffolds via [3+2] cycloaddition or Paal–Knorr-type cyclizations. Its conjugated enoic acid structure provides stability and facilitates electrophilic functionalization at the β-position, while the chlorine atom offers a handle for nucleophilic substitution or metal-catalyzed cross-coupling reactions. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H290-H314
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Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501
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Lot numbers can be found on the outside label of a product: