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CS-W001157 4
Total: USD 88.00

2-Bromo-1-(4-ethylphenyl)ethanone

  • CAS No. 2632-14-6

  • Cat. No. CS-W006339
  • Purity≥98%
  • MDL No.MFCD00981997

*For research and further manufacturing use only, not for direct human use.

2-Bromo-1-(4-ethylphenyl)ethanone|CS-W006339

Structure of 2632-14-6

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General Information

  • CAS No. 2632-14-6
  • Cat. No. CS-W006339
  • Purity ≥98%
  • MDL No. MFCD00981997
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁BrO
  • Molecular Weight None
  • Synonym(s) 2-bromo-4-ethylacetophenone
  • SMILES CCC1=CC=C(C=C1)C(=O)CBr

Description

2-Bromo-1-(4-ethylphenyl)ethanone is a brominated aryl ketone featuring a para-ethyl-substituted phenyl ring and a reactive acyl bromide functionality. This bench-stable compound integrates readily into synthetic sequences requiring electrophilic aryl transfer or C–C bond formation. Its electron-deficient carbonyl group enables efficient coupling reactions under mild conditions, facilitating access to complex aromatic architectures in medicinal chemistry and materials synthesis.

Application

2-Bromo-1-(4-ethylphenyl)ethanone serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized aryl ketones and heterocyclic scaffolds. Its bromo substituent facilitates subsequent cross-coupling reactions, while the ethylphenyl group provides structural rigidity and enhanced lipophilicity. The compound exhibits good bench stability, ease of purification, and compatibility with standard reaction conditions, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • PFIZER PRODUCTS INC. Patent: WO2008/84300 A1, 2008 ; Location in patent: Page/Page column 35 ; WO 2008/084300 A1
  • Route2
    • In-stock
      1-(4-Ethylphenyl)ethanone|CS-W021233
      937-30-4
    • ~89%
    • In-stock
      2-Bromo-1-(4-ethylphenyl)ethanone|CS-W006339
      2632-14-6
    • null|null
      41036-98-0

    References

    • Mohan Reddy, Bodireddy; Venkata Ramana Kumar, Velpula; Chinna Gangi Reddy, Nallagondu; Mahender Rao, Siripragada Chinese Chemical Letters, 2014 , vol. 25, # 1 p. 179 - 182
  • Route3
    • null|null
      1345683-42-2
    • ~96%
    • In-stock
      2-Bromo-1-(4-ethylphenyl)ethanone|CS-W006339
      2632-14-6

    References

    • Chen, Zheng-Wang; Ye, Dong-Nai; Ye, Min; Zhou, Zhong-Gao; Li, Shen-Huan; Liu, Liang-Xian Tetrahedron Letters, 2014 , vol. 55, # 7 p. 1373 - 1375

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H290-H302-H314-H318
Precautionary Statements : P234-P260-P264-P270-P280-P301+P310-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P363-P390-P405-P406-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.8266
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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