Tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate

Name: Tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate
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CAS No. 263162-13-6
Cat. No. CS-0336130
Purity≥97%
MDL No.MFCD18831537

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate|CS-0336130

Structure of 263162-13-6

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General Information

CAS No. 263162-13-6
Cat. No. CS-0336130
Purity ≥97%
MDL No. MFCD18831537
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₃N₃O₂
Molecular Weight 217.31
Synonym(s) None
SMILES O=C(OC(C)(C)C)NCCN(C)CCN

Description

Tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate features a bifunctional amine handle with tunable basicity, enabling efficient conjugation in bioconjugation workflows. The tert-butyl carbamate group provides robust protection under standard conditions while allowing facile deprotection. This scaffold integrates seamlessly into peptide and oligonucleotide synthesis applications.

Application

Tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate serves as a versatile bifunctional protecting group reagent, enabling selective amino protection in peptide synthesis and late-stage functionalization. Its tert-butyl carbamate moiety offers excellent bench stability and mild acid-labile deprotection, while the pendant primary amine facilitates conjugation or further derivatization. Functions effectively in aqueous and organic media with high compatibility across standard coupling protocols.

Synthesis

Route1
- In-stock
  
  4097-88-5
- In-stock
  
  24424-99-5
- ~85%
- In-stock
  
  263162-13-6
References
- Palus; Chojnacka; Piasecki; Zboinska; Mlochowski Polish Journal of Chemistry, 2004 , vol. 78, # 11-12 p. 2117 - 2126
Route2
- In-stock
  
  4097-88-5
- In-stock
  
  34619-03-9
- ~%
- In-stock
  
  263162-13-6
References
- CATABASIS PHARMACEUTICALS, INC.; MILNE, Jill, C.; JIROUSEK, Michael, R.; BEMIS, Jean, E.; VU, Chi, B.; TING, Amal Patent: WO2012/115695 A1, 2012 ; Location in patent: Page/Page column 78-79 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

TPSA 67.59
LogP 0.4016
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 5

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Amine

Key Words

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Tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate

CAS No. 263162-13-6

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