Lot numbers can be found on the outside label of a product:
2,4-Dihydroxy-5,6-dimethylpyrimidine
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CAS No. 26305-13-5
- Cat. No. CS-W005613
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 26305-13-5
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General Information
- CAS No. 26305-13-5
- Cat. No. CS-W005613
- Purity ≥98%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₈N₂O₂
- Molecular Weight 140.14
- Synonym(s) 5,6-dimethylpyrimidine-2,4(1H,3H)-dione
- SMILES CC(C(N1)=O)=C(NC1=O)C
Description
2,4-Dihydroxy-5,6-dimethylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, featuring two hydroxyl groups flanking a methyl-substituted pyrimidine core. This arrangement enables robust hydrogen bonding and enhanced solubility, supporting its role in bioactive molecule design. The compound exhibits bench-stable handling under standard conditions and integrates efficiently into synthetic sequences requiring polar, electron-rich platforms.
Application
2,4-Dihydroxy-5,6-dimethylpyrimidine serves as a versatile building block for heterocyclic synthesis, particularly in the construction of pyrimidine-based scaffolds relevant to medicinal chemistry. Its ortho-diol functionality enables selective derivatization and metal coordination, while the methyl groups enhance stability and modulate reactivity. The compound exhibits bench stability and facilitates straightforward purification, making it well-suited for use in iterative synthesis workflows and API intermediate development.
Synthesis
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References
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Burgula, Laxmi Narayana; Radhakrishnan; Kundu, Lal Mohan Tetrahedron Letters, 2012 , vol. 53, # 21 p. 2639 - 2642
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Route2
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In-stock
28456-54-4 - ~78%
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In-stock
26305-13-5
References
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ABBVIE INC.; DEKHTYAR, Tatyana; GOMTSYAN, Arthur; MOLLA, M-Akhteruzzaman; VASUDEVAN, Anil; NG, Teresa (Iok Chan); SHAFEEV, Mikhail Patent: WO2013/123401 A1, 2013 ; Location in patent: Page/Page column 40 ;
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Route3
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138395-56-9 - ~69%
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In-stock
26305-13-5
References
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Botta; Summa; Saladino; Nicoletti Synthetic Communications, 1991 , vol. 21, # 21 p. 2181 - 2187
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 65.72
- LogP -0.31996
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 0
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Key Words
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