N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide

Name: N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 262368-30-9
Cat. No. CS-M0380
Molecule weight262.36
Purity≥95%
MDL No.MFCD12457658

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide|CS-M0380

Structure of 262368-30-9

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General Information

CAS No. 262368-30-9
Cat. No. CS-M0380
Purity ≥95%
MDL No. MFCD12457658
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₂N₄O
Molecular Weight 262.36
Synonym(s) None
SMILES O=C(CN1CCN(C)CC1)N(C)C(C=C2)=CC=C2N

Description

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide features a conjugated aniline handle paired with a sterically hindered piperazinyl acetyl side chain, enabling efficient coupling in bioconjugation workflows. The molecule combines enhanced solubility with bench-stable reactivity under standard conditions.

Application

N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through standard amide coupling and cyclization protocols. Its dual functionality—aromatic amine and tertiary amide—supports efficient derivatization under mild conditions, while the piperazine moiety enhances solubility and metabolic stability. The compound exhibits excellent bench stability and compatibility with common purification techniques, facilitating scalable synthesis in drug discovery workflows.

Synthesis

Route1
- In-stock
  
  109-01-3
- In-stock
  
  2653-16-9
- ~70%
- In-stock
  
  262368-30-9
References
- WO2012/68441 A2, ; Page/Page column 13; 14 ;
Route2
- 1139453-98-7
- ~80%
- In-stock
  
  262368-30-9
References
- Journal of Medicinal Chemistry, , vol. 52, # 14 p. 4466 - 4480
Route3
- 100-15-2
- ~%
- In-stock
  
  262368-30-9
References
- WO2012/68441 A2, ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 52.81
LogP 0.479
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide

CAS No. 262368-30-9

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