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CS-W001157 4
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Ethyl 4-(2-chloroacetamido)benzoate

  • CAS No. 26226-72-2

  • Cat. No. CS-0188266
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 4-(2-chloroacetamido)benzoate|CS-0188266

Structure of 26226-72-2

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General Information

  • CAS No. 26226-72-2
  • Cat. No. CS-0188266
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂ClNO₃
  • Molecular Weight 241.67
  • Synonym(s) Ethyl 4-[(chloroacetyl)amino]benzoate
  • SMILES CCOC(=O)C1=CC=C(C=C1)NC(=O)CCl

Description

Ethyl 4-(2-chloroacetamido)benzoate features a strategically positioned chloroacetamido group that enhances reactivity in amide coupling workflows. This electron-deficient aromatic ester integrates readily into peptide synthesis and medicinal chemistry scaffolds, offering reliable stability under standard conditions.

Application

Ethyl 4-(2-chloroacetamido)benzoate serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted benzamide derivatives. The chloroacetamido group facilitates nucleophilic displacement reactions, while the ester functionality supports selective transformations under mild conditions. Its bench-stable nature and compatibility with common coupling protocols make it ideal for constructing pharmacophores in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.4
  • LogP   2.0406
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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