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CS-W001157 4
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2-(8-Ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 2621932-48-5

  • Cat. No. CS-0529950
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(8-Ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0529950

Structure of 2621932-48-5

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General Information

  • CAS No. 2621932-48-5
  • Cat. No. CS-0529950
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₆BFO₄
  • Molecular Weight 360.23
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(C2=C3C(CC)=C(F)C=CC3=CC(OCOC)=C2)O1

Description

This boronate ester features a naphthalene core functionalized with an ethyl, fluoro, and methoxymethoxy group at the 8-, 7-, and 3-positions, respectively. The tetramethyl-substituted dioxaborolane moiety enables stable coupling in Suzuki-Miyaura reactions under standard conditions. Designed for efficient C–C bond formation in complex molecule synthesis, this reagent offers excellent shelf stability and handles well in air-sensitive protocols.

Application

This boronate ester serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The naphthalene core features orthogonal functional groups—ethyl, fluoro, and methoxymethoxy—that support further derivatization while maintaining stability during storage and handling. Its tetramethyl-substituted dioxaborolane ring enhances shelf life and facilitates purification, making it ideal for iterative synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   3.8232
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   5

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