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CS-W001157 4
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Methyl 6-methoxynicotinate

  • CAS No. 26218-80-4

  • Cat. No. CS-W005354
  • Purity≥98%
  • MDL No.MFCD00674130

*For research and further manufacturing use only, not for direct human use.

Methyl 6-methoxynicotinate|CS-W005354

Structure of 26218-80-4

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General Information

  • CAS No. 26218-80-4
  • Cat. No. CS-W005354
  • Purity ≥98%
  • MDL No. MFCD00674130
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) METHYL 6-METHOXYPYRIDINE-3-CARBOXYLATE
  • SMILES O=C(OC)C1=CN=C(OC)C=C1

Description

Methyl 6-methoxynicotinate is a bench-stable, moisture-tolerant ester featuring a para-methoxy-substituted pyridine core. This electron-rich heterocycle integrates readily into synthetic sequences requiring polar, stable building blocks. The methoxy group enhances solubility in common organic solvents while maintaining compatibility with standard coupling and functionalization protocols.

Application

Methyl 6-methoxynicotinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to pyridine-based scaffolds through standard functional group transformations. Its methyl ester and methoxy substituents provide orthogonal reactivity for selective derivatization, while the stability under common reaction conditions facilitates straightforward purification and scale-up. Functions effectively in coupling reactions and heterocycle synthesis relevant to medicinal chemistry and agrochemical development.

Synthesis

  • Route1

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 227 - 234
  • Route2
    • null|null
      67-56-1
    • In-stock
      5-Bromo-2-methoxypyridine|CS-D0943
      13472-85-0
    • null|null
      201230-82-2
    • ~73%
    • In-stock
      Methyl 6-methoxynicotinate|CS-W005354
      26218-80-4

    References

    • Journal of Organometallic Chemistry, , vol. 695, # 2 p. 260 - 266
  • Route3
    • null|null
      124-41-4
    • null|null
      705931-67-5
    • ~98%
    • In-stock
      Methyl 6-methoxynicotinate|CS-W005354
      26218-80-4

    References

    • Organic Preparations and Procedures International, , vol. 35, # 6 p. 623 - 626

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.42
  • LogP   0.8768
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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