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CS-W001157 4
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Methyl 6-bromopicolinate

  • CAS No. 26218-75-7

  • Cat. No. CS-M1028
  • Purity≥98%
  • MDL No.MFCD06203934

*For research and further manufacturing use only, not for direct human use.

Methyl 6-bromopicolinate|CS-M1028

Structure of 26218-75-7

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General Information

  • CAS No. 26218-75-7
  • Cat. No. CS-M1028
  • Purity ≥98%
  • MDL No. MFCD06203934
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₂
  • Molecular Weight 216.03
  • Synonym(s) None
  • SMILES O=C(OC)C1=NC(Br)=CC=C1

Description

Methyl 6-bromopicolinate features a brominated pyridine ring with a methyl ester handle, enabling direct functionalization in cross-coupling and nucleophilic substitution reactions. This bench-stable derivative integrates readily into complex heterocyclic scaffolds under standard conditions.

Application

Methyl 6-bromopicolinate serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the C-6 position via palladium-catalyzed cross-coupling reactions. Its bromine substituent exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the ester group provides orthogonal handle for further transformations. The compound demonstrates excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis of heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6307
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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