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Structure of 261952-01-6
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4-Methyl-3-(trifluoromethyl)benzoic acid features a sterically accessible carboxyl group flanked by electron-withdrawing trifluoromethyl and methyl substituents, enabling enhanced reactivity in coupling reactions. This robust scaffold integrates readily into bioactive molecules requiring high metabolic stability and controlled lipophilicity.
4-Methyl-3-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry and materials science, offering enhanced lipophilicity and metabolic stability due to the trifluoromethyl group. Its carboxylic acid functionality enables direct coupling reactions, while the methyl and trifluoromethyl substituents provide orthogonal reactivity for further functionalization. The compound exhibits excellent bench stability and is compatible with standard synthetic protocols, facilitating efficient access to diverse heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: