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Structure of 261951-69-3
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This bench-stable arylamine features a fluorinated aromatic ring and a methyl substituent that enhance electronic tuning and metabolic stability. The primary amine group enables straightforward functionalization in amide coupling, Suzuki-Miyaura cross-coupling, and other transformations common to pharmaceutical intermediates.
(5-Fluoro-2-methylphenyl)methanamine serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic amines through standard amine functionalization and coupling reactions. Its ortho-methyl and meta-fluoro substituents provide enhanced metabolic stability and modulated electronic properties, facilitating efficient incorporation into bioactive scaffolds. The compound exhibits good bench stability, compatibility with common protecting group strategies, and ease of purification via standard chromatographic methods, making it well-suited for iterative synthetic workflows in API development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314-H318
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: