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CS-W001157 4
Total: USD 88.00

(4-Bromophenyl)methanamine hydrochloride

  • CAS No. 26177-44-6

  • Cat. No. CS-W013111
  • Purity≥98%
  • MDL No.MFCD00012860

*For research and further manufacturing use only, not for direct human use.

(4-Bromophenyl)methanamine hydrochloride|CS-W013111

Structure of 26177-44-6

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General Information

  • CAS No. 26177-44-6
  • Cat. No. CS-W013111
  • Purity ≥98%
  • MDL No. MFCD00012860
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BrClN
  • Molecular Weight 222.51
  • Synonym(s) 4-Bromobenzylamine hydrochloride
  • SMILES BrC1=CC=C(CN)C=C1.Cl

Description

4-Bromobenzylamine hydrochloride was used to study the characteristics of C-terminal polyamine modification in the presence of protease and amine.

Application

(4-Bromophenyl)methanamine hydrochloride serves as a versatile building block for the synthesis of pharmaceutically relevant arylamines. Its robust bench stability and high functional group tolerance enable reliable use in Suzuki-Miyaura couplings, Buchwald-Hartwig amination, and direct electrophilic substitution. The bromo substituent facilitates downstream diversification, while the amine functionality provides a handle for salt formation and derivatization. This compound functions effectively in both small-molecule discovery and process-scale synthesis.

Synthesis

  • Route1
    • null|null
      25062-46-8
    • ~82%
    • In-stock
      (4-Bromophenyl)methanamine hydrochloride|CS-W013111
      26177-44-6

    References

    • AlliedSignal Inc. Patent: US6340773 B1, 2002 ; Location in patent: Example 1 ;
  • Route2
    • null|null
      107047-10-9
    • ~93%
    • In-stock
      (4-Bromophenyl)methanamine hydrochloride|CS-W013111
      26177-44-6

    References

    • Pal, Bikash; Jaisankar, Parasuraman; Giri, Venkatachalam S. Synthetic Communications, 2004 , vol. 34, # 7 p. 1317 - 1323
  • Route3

    References

    • Reeves, Jonathan T.; Tan, Zhulin; Marsini, Maurice A.; Han, Zhengxu S.; Xu, Yibo; Reeves, Diana C.; Lee, Heewon; Lu, Bruce Z.; Senanayake, Chris H. Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 47 - 52

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.3296
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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