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CS-W001157 4
Total: USD 88.00

1-Chloro-2-fluoro-3-methoxybenzene

  • CAS No. 261762-56-5

  • Cat. No. CS-W021315
  • Molecule weight160.57
  • Purity≥98%
  • MDL No.MFCD01631570

*For research and further manufacturing use only, not for direct human use.

1-Chloro-2-fluoro-3-methoxybenzene|CS-W021315

Structure of 261762-56-5

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General Information

  • CAS No. 261762-56-5
  • Cat. No. CS-W021315
  • Purity ≥98%
  • MDL No. MFCD01631570
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClFO
  • Molecular Weight 160.57
  • Synonym(s) Benzene, 1-chloro-2-fluoro-3-methoxy-
  • SMILES ClC1=CC=CC(=C1F)OC

Description

1-Chloro-2-fluoro-3-methoxybenzene features a trifunctional aromatic core with orthogonal reactivity, enabling selective transformations in medicinal chemistry. The electron-withdrawing chlorine and fluorine atoms enhance electrophilic substitution control, while the methoxy group provides a polar handle for coupling reactions. This combination delivers high functional group tolerance and stability under standard conditions.

Application

1-Chloro-2-fluoro-3-methoxybenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chloro and fluoro substituents offer complementary reactivity profiles, while the methoxy group enhances solubility and modulates electronic properties. Its bench-stable nature and compatibility with standard synthetic protocols facilitate efficient access to functionalized aryl scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.4877
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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