6-Chloro-4-(trifluoromethyl)nicotinic acid

Name: 6-Chloro-4-(trifluoromethyl)nicotinic acid
Brand: ChemScene
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CAS No. 261635-77-2
Cat. No. CS-0041939
Purity≥98%
MDL No.MFCD06800446

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-4-(trifluoromethyl)nicotinic acid|CS-0041939

Structure of 261635-77-2

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General Information

CAS No. 261635-77-2
Cat. No. CS-0041939
Purity ≥98%
MDL No. MFCD06800446
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClF₃NO₂
Molecular Weight 225.55
Synonym(s) 6-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid
SMILES O=C(O)C1=CN=C(Cl)C=C1C(F)(F)F

Description

6-Chloro-4-(trifluoromethyl)nicotinic acid features a trifluoromethyl group at the 4-position and a chlorine substituent at the 6-position of the pyridine ring, imparting strong electron-withdrawing character. This configuration enhances reactivity in coupling reactions and improves metabolic stability in pharmaceutical applications. The compound serves as a key building block for bioactive heterocycles and advanced synthetic intermediates.

Application

6-Chloro-4-(trifluoromethyl)nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro substituent provides a handle for further functionalization. Bench-stable and readily purified, it functions effectively in standard synthetic workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 50.19
LogP 2.452
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-4-(trifluoromethyl)nicotinic acid

CAS No. 261635-77-2

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