1-Chloro-4-iodo-2-(trifluoromethyl)benzene

Name: 1-Chloro-4-iodo-2-(trifluoromethyl)benzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 260355-20-2
Cat. No. CS-W012088
Purity≥98%
MDL No.MFCD09037801

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Chloro-4-iodo-2-(trifluoromethyl)benzene|CS-W012088

Structure of 260355-20-2

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 260355-20-2
Cat. No. CS-W012088
Purity ≥98%
MDL No. MFCD09037801
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClF₃I
Molecular Weight 306.45
Synonym(s) 2-Chloro-5-iodobenzotrifluoride
SMILES FC(F)(F)C1=C(Cl)C=CC(I)=C1

Description

1-Chloro-4-iodo-2-(trifluoromethyl)benzene features a trifluoromethyl group flanked by orthogonal halogens, enabling selective cross-coupling in late-stage functionalization. The chlorine and iodine sites support sequential or divergent transformations under palladium catalysis, offering high chemoselectivity and stability under standard conditions.

Application

1-Chloro-4-iodo-2-(trifluoromethyl)benzene serves as a versatile biaryl building block in cross-coupling chemistry, enabling efficient Pd-catalyzed transformations such as Suzuki-Miyaura and Stille reactions. The orthogonal reactivity of the chloro and iodo groups allows for sequential functionalization, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and readily purified, it facilitates streamlined synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 0
LogP 3.9634
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

260355-20-2 sigma260355-20-2 manufacturer260355-20-2 price260355-20-2 structure260355-20-2 SDSbuy 260355-20-2260355-20-2 supplier260355-20-2 uses260355-20-2 molecular weightprice of 260355-20-2260355-20-2 chemical name formula of 260355-20-2

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-Chloro-4-iodo-2-(trifluoromethyl)benzene

CAS No. 260355-20-2

Recommended Products