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CS-W001157 4
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Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

  • CAS No. 25940-35-6

  • Cat. No. CS-W013252
  • Purity≥97%
  • MDL No.MFCD01975194

*For research and further manufacturing use only, not for direct human use.

Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid|CS-W013252

Structure of 25940-35-6

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General Information

  • CAS No. 25940-35-6
  • Cat. No. CS-W013252
  • Purity ≥97%
  • MDL No. MFCD01975194
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃O₂
  • Molecular Weight 163.14
  • Synonym(s) Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid(WX614223)
  • SMILES OC(=O)C1=C2N=CC=CN2N=C1

Description

Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid features a fused heterocyclic core with a carboxylic acid group at the 3-position, enabling direct conjugation in medicinal chemistry. This scaffold integrates into bioactive molecules where planarity and hydrogen bonding capacity enhance target affinity. The electron-deficient ring system supports diverse functionalization for drug discovery applications.

Application

Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds through standard coupling and cyclization protocols. Its carboxylic acid functionality facilitates direct amide formation, esterification, and metal-catalyzed cross-coupling reactions. The rigid, electron-deficient core exhibits favorable stability and solubility profiles, supporting straightforward purification and integration into medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   67.49
  • LogP   0.4275
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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