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CS-W001157 4
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tert-Butyl 4-hydroxybenzoate

  • CAS No. 25804-49-3

  • Cat. No. CS-W023012
  • Purity≥98%
  • MDL No.MFCD09953072

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-hydroxybenzoate|CS-W023012

Structure of 25804-49-3

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General Information

  • CAS No. 25804-49-3
  • Cat. No. CS-W023012
  • Purity ≥98%
  • MDL No. MFCD09953072
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄O₃
  • Molecular Weight 194.23
  • Synonym(s) Benzoicacid, p-hydroxy-, tert-butyl ester (8CI)
  • SMILES O=C(OC(C)(C)C)C1=CC=C(O)C=C1

Description

tert-Butyl 4-hydroxybenzoate features a sterically hindered tert-butyl ester group that enhances stability and solubility in organic media. The para-hydroxyl functionality provides a reactive handle for downstream derivatization, while the aromatic core offers rigidity and electron-rich character. This combination enables reliable use in synthetic routes requiring bench-stable, moisture-tolerant phenolic intermediates.

Synthesis

  • Route1
    • null|null
      75-65-0
    • 4-Hydroxybenzoic acid  Cetirizine Impurity|CS-0167040
      99-96-7
    • ~95%
    • In-stock
      tert-Butyl 4-hydroxybenzoate|CS-W023012
      25804-49-3

    References

    • Iqbal, Parvez; Critchley, Kevin; Bowen, James; Attwood, David; Tunnicliffe, David; Evans, Stephen D.; Preece, Jon A. Journal of Materials Chemistry, 2007 , vol. 17, # 48 p. 5097 - 5110
  • Route2

    References

    • Heiney, Paul A.; Stetzer, MacKenzie R.; Mindyuk, Oksana Y.; DiMasi, Elaine; McGhie, Andrew R.; Liu, Hu; Smith III, Amos B. Journal of Physical Chemistry B, 1999 , vol. 103, # 30 p. 6206 - 6214
  • Route3

    References

    • Goossen; Doehring Advanced Synthesis and Catalysis, 2003 , vol. 345, # 8 p. 943 - 947

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.3475
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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